Enhancement of the cytotoxic action of chemotherapy drugs by alkylating compounds: a model for cyclophosphamide.
The relations between plasma pharmacokinetics, biochemical effects in target tissues, and therapeutic consequences were examined for alkylating agents as well as antioxidants of the blood. The data on the relationship between plasma pharmacokinetics and antitumor efficacy obtained in this way have led us to propose a chemotherapy model comprising dosing schedules which are highly ef